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Methodology/Principal Findings

We demonstrate that impregnation of copper oxide into respiratory protective face masks endows them with potent biocidal properties in addition to their inherent filtration properties. Both control and copper oxide impregnated masks filtered above 99.85% of aerosolized viruses when challenged with 5.66±0.51 and 6.17±0.37 log₁₀TCID₅₀ of human influenza A virus (H1N1) and avian influenza virus (H9N2), respectively, under simulated breathing conditions (28.3 L/min). Importantly, no infectious human influenza A viral titers were recovered from the copper oxide containing masks within 30 minutes (≤0.88 log₁₀TCID₅₀), while 4.67±1.35 log₁₀TCID₅₀ were recovered from the control masks. Similarly, the infectious avian influenza titers recovered from the copper oxide containing masks were ≤0.97±0.01 log₁₀TCID₅₀ and from the control masks 5.03±0.54 log₁₀TCID₅₀. The copper oxide containing masks successfully passed Bacterial Filtration Efficacy, Differential Pressure, Latex Particle Challenge, and Resistance to Penetration by Synthetic Blood tests designed to test the filtration properties of face masks in accordance with the European EN 14683:2005 and NIOSH N95 standards.

New research from the University of Southampton has found that copper can effectively help to prevent the spread of respiratory viruses, which are linked to severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS).

Animal coronaviruses that 'host jump' to humans, such as SARS and MERS, result in severe infections with high mortality. The Southampton researchers found that a closely-related human coronavirus -- 229E -- can remain infectious on common surface materials for several days, but is rapidly destroyed on copper.

A newly-published paper in mBio -- a journal of the American Society for Microbiology -- reports that human coronavirus 229E, which produces a range of respiratory symptoms from the common cold to more lethal outcomes such as pneumonia, can survive on surface materials including ceramic tiles, glass, rubber and stainless steel for at least five days. While human-to-human transmission is important, infections can be contracted by touching surfaces contaminated by respiratory droplets from infected individuals, or hand touching, leading to a wider and more rapid spread

On copper, and a range of copper alloys -- collectively termed 'antimicrobial copper' -- the coronavirus was rapidly inactivated (within a few minutes, for simulated fingertip contamination). Exposure to copper destroyed the virus completely and irreversibly, leading the researchers to conclude that antimicrobial copper surfaces could be employed in communal areas and at any mass gatherings to help reduce the spread of respiratory viruses and protect public health.

Lead researcher Dr Sarah Warnes said: "Transmission of infectious diseases via contaminated surfaces is far more important than was originally thought, and this includes viruses that cause respiratory infections. This is especially important when the infectious dose is low and just a few virus particles can initiate an infection.

"Human coronavirus, which also has ancestral links with bat-like viruses responsible for SARS and MERS, was found to be permanently and rapidly deactivated upon contact with copper. What's more, the viral genome and structure of the viral particles were destroyed, so nothing remained that could pass on an infection. With the lack of antiviral treatments, copper offers a measure that can help reduce the risk of these infections spreading."

Speaking on the importance of the study, Professor Bill Keevil, co-author and Chair in Environmental Healthcare at the University of Southampton, said: "Respiratory viruses are responsible for more deaths, globally, than any other infectious agent. The evolution of new respiratory viruses, and the re-emergence of historic virulent strains, poses a significant threat to human health.

"The rapid inactivation and irreversible destruction of the virus observed on copper and copper alloy surfaces suggests that the incorporation of copper alloy surfaces -- in conjunction with effective cleaning regimes and good clinical practice -- could help control transmission of these viruses."

Previous research by Professor Keevil and Dr Warnes has proved copper's efficacy against norovirus, influenza and hospital superbugs, such as MRSA and Klebsiella, plus stopping the transfer of antibiotic resistance genes to other bacteria to create new superbugs.

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Materials provided by University of Southampton.